Motor-neuron-diseases-Case-Ms. Meng

Case：Ms. Meng from China

Nationality：

China

Age：

57 years old

Diagnosis：

Motor neuron diseases

First Admission Date：

Apr 2006

Second Admission Date：

May 2007

Background

Ms. Meng is a Chinese 57 years old female patient suffering from motor neuron disease (ALS). Her disease onset is from 2002, she was diagnosed as motor neuron disease in the 3rd hospital of Beijing University. She received 1st round stem cell treatment in our hospital in April, 2006, 4 years after her disease onset.

Pre-Treatment Condition（Before Stem Cell Treatment）

1.Her shoulder muscles atrophied and were sore, especially the left side, the escaping muscles, the big and small thenar muscles of her both hands atrophied;
2.Her breath was difficult during lying on back;
3.Her left hand could not make a fist;
4.Her left upper limb could not lift up, the muscle strength of her lower limbs was weak, she could not go upstairs;
5.The muscle jump on her left face and limbs could be checked obviously.

Treatment Plan

Two courses of stem cell therapy
Surgical method: Lumbar puncture
Efficacy monitoring plan over 6 to 12 months post-treatment

After the First Course ofTreatment (6 months)

1. The pain of her shoulders is disappeared;
2.She can breathe more easily during lying on back, she can lie on back continuously for 5-6 hours;
3.Her chest distress after sports is relieved obviously;
4. She can lift up her left hand higher obviously, her fingers can stretch straight slowly, the muscle strength of her fingers is improved obviously, her left hand is able to assist her right hand to do some simple daily work;
5. The muscle strength of her lower limbs is improved obviously;
6.The muscle jump of her whole body is disappeared.

After the Second Course ofTreatment (12 months)

1.The movement range of her both hands is increased;
2.The muscle power and flexibility of her both hands is improved obviously.

Symptom	Improvement
Severe atrophy and soreness (left side dominant); weakened thenar muscles.	Shoulder pain resolved; partial muscle recovery.
Difficulty breathing in supine position.	Sustained supine breathing (5-6 hours); reduced chest tightness post-exercise.
Inability to make a fist; poor grip strength.	Improved finger extension and strength; assists right hand in daily tasks.
Left arm immobility; weak lower limbs (unable to climb stairs).	Left arm lifting ability restored; lower limb strength improved.
Visible involuntary jumps (left face/limbs).	Complete resolution of body-wide fasciculations.

Progress Summary & Future Outlook

Ms. Meng's current progress after stem cell treatments is highly encouraging, and the future holds great promise for her. In the coming days, we anticipate a continued upward trajectory in her physical condition.

With each treatment and continued rehabilitation, Mrs. Meng has the potential to lead a life with minimal limitations imposed by ALS, fully embracing daily life and social interactions.