Motor-neuron-diseases-Case-Mr. Wang

Case：Mr. Wang from China

Nationality：

China

Age：

27 years old

Diagnosis：

Motor neuron diseases

Admission Date：

Dec 2010

Background

Mr. Wang Jia, a 27-year-old individual, had his life irrevocably altered when, in 2008, he was diagnosed with Amyotrophic Lateral Sclerosis (ALS). This neurodegenerative disorder, also known as Lou Gehrig's disease, is characterized by the progressive degeneration of motor neurons in the brain and spinal cord, leading to a gradual loss of muscle control.

Since the diagnosis, the disease has been relentlessly advancing. By the time 2010 rolled around, his condition had deteriorated to the late - stage of ALS. Facing a critical juncture in his battle against this debilitating illness, he opted for a potentially life-changing treatment approach: stem cell treatment. This procedure, with its promise of replenishing damaged cells and potentially halting the progression of ALS, became his new hope in the arduous journey towards recovery or at least the stabilization of his condition.

Pre-Treatment Condition（Before Stem Cell Treatment）

1. Speech Impairment

- Slurred, jumbled speech due to ALS motor neuron damage.

- Impaired communication leading to frustration and isolation.

2. Swallowing Difficulties

- Weakened swallowing muscles from ALS progression.

- Laborious eating, high choking risk, aspiration pneumonia threat.

3. High Muscle Tension in Limbs

- Severe limb rigidity and pain from elevated muscle tension.

- Restricted mobility, hindering basic physical tasks.

4. Limb Weakness and Paralysis

- Near-complete paralysis; only right index finger functional.

- Reliance on minimal movement for interaction and full-time care.

5. Muscle Atrophy

- Visible muscle wasting from nerve signal loss.

- Declining strength and endurance exacerbating physical limitations.

Treatment Plan

One course of stem cell therapy
Surgical method: Lumbar puncture
Efficacy monitoring plan over 1 to 12 months post-treatment

After the First Course ofTreatment (1 month)

1. Remarkable Speech Improvement
- Clearer pronunciation and intelligible speech post-surgery.
- Enhanced communication, boosting confidence and social interaction.
2. Enhanced Swallowing Function
- Improved swallowing muscle coordination and strength.
- Reduced meal duration, lower choking risk, and normalized eating experience.
3. Alleviated Body Weakness
- Increased energy and endurance for daily tasks.
- Ability to sit longer without fatigue, improving daily engagement.
4. Reduced Muscle Tension
- Decreased limb stiffness and discomfort.
- Expanded range of motion for complex movements (e.g., reaching, adjusting posture).
5. Increased Limb Muscle Strength
- Partial restoration of muscle strength, notably in the right hand.
- Improved grip functionality for basic tasks and physical therapy participation.

Symptom	Improvement
Slurred, jumbled speech due to ALS motor neuron damage.	Clearer pronunciation; enhanced communication.
Laborious eating, high choking/aspiration risk.	Strengthened coordination; shorter meal duration.
Severe rigidity, restricted limb mobility.	Reduced stiffness; expanded range of motion.
Near-total paralysis (only right index finger functional).	Partial strength restoration; improved grip function.
Extreme fatigue, limited endurance.	Higher energy levels; prolonged sitting tolerance.

Progress Summary & Future Outlook

Mr. Wang Jia's current improvements are highly promising. With clearer speech, he'll be able to communicate more effectively in both personal and professional settings, potentially reconnecting with old friends and engaging in work-related discussions. His enhanced swallow ability ensures better nutrition intake, which will further boost his overall health.

The alleviated body weakness, reduced muscle tension, increased muscle strength, and improved muscle volume suggest he can gradually regain more physical independence.