Motor-neuron-diseases-Case-Mr T

Case：Mr T from Myanmar

Age：

62 years old

Nationality：

Myanmar

Diagnosis：

Motor neuron diseases

First Admission Date：

March 2017

Second Admission Date：

July 2017

Background

Mr. T is a prestigious entrepreneur and philanthropist in Myanmar. He gave multiple donations to build a number of temples, bridges, schools, nursing homes, and has been repeatedly reported by domestic and foreign media. However, when confronting with severe illness, he is also fragile. He was diagnosed with Motor Neuron Disease (MND, also known as ALS) in January 2014. After diagnosis, he went for treatment in the United States, Germany, Japan, Singapore, Thailand, but no significant improvement has been obtained.

Patient’s family member consulted our stem cells treatment department in January 2017. Our medical expert team went to the patient's national army hospital in March 2017 and conducted four times biological treatment as first round of treatment. After that, the patient’s symptoms improved significantly and the conditions is under controlled. The patient accepted a second round of treatment in July 2017.

Pre-Treatment Condition（Before Stem Cell Treatment）

1. Patient has breathing difficulty; tongue muscle atrophied and cannot be extended extraoral; speech blurred and blunt; drooling frequently and unable to swallow.
2. Liquid food fed via PEG tube, solid food fed through mouth with difficulty. It takes 30 minutes for each meal, cannot drink through mouth, otherwise he could be choked easily.
3. Weak muscle strength, unable to lift upper limbs, unable to hold or grab anything by each hand, unable to bend and stretch his fingers, unable to move, bend or stretch his legs, and both feet are tip-toed.
4. Coldness of four limbs, severe muscle atrophy of four limbs, remarkable muscular atrophy of thenar eminence, hypothenar eminence, palmar interossei, upper limbs, scapular muscles, and leg muscles.
5. Stiffness of whole body, fatigue, poor mental state, poor sleep quality.

Treatment Plan

Two courses of stem cell therapy
Surgical method: lumbar puncture + Intravenous infusion
Efficacy monitoring plan over 6 to 12 months post-treatment

After the First Course ofTreatment (6 months)

1. Easier to breath, he can shortly breathe (about3 minutes) without ventilator while lying down. Tongue muscle regrowth and flattened, able to be extended extraoral and draw back his tongue freely, clear and fluent speech.
2. Swallow easily, dining time shortened to 15 minutes; able to drink water easily without choking, less saliva and drooling;
3. Able to lift upper limbs freely, muscle strength of wrists increased, fingers flexible, able to bend; able to bend and stretch lower limbs, feet can touch floor flatly and be flexible;
4. Feel warmth of four limbs; muscles regrowth and fullness of his fingers, palmar interossei, and thenar eminence;
5. Body stiffness and tightness disappeared, better sleep quality, good mental state, blood pressure and blood sugar well controlled without any medication.

After the Second Course ofTreatment (12 months)

1. Breathing
- Voluntarily discontinued ventilator use; independent breathing extended to 1.25 hours.
- Significant reduction in lung inflammation.
2. Swallowing
- Upbeat mood and increased appetite.
- Enhanced lip closure and chewing strength during meals.
- Safer swallowing with reduced choking risk.
3. Limbs
- Pain-triggered foot retraction reflex restored (neuromotor improvement).
- Reduced muscle tone in feet; ability to place feet flat for gait balance.
- Overall body relaxation and improved mobility.
4. Peripheral Circulation
- Improved limb circulation via acupoint massage and moxibustion.
- Warmer limbs post-treatment, aiding tissue repair.
5. Overall Rehabilitation
- Strict adherence to rehabilitation; excellent mental state and positivity.
- Slightly improved sleep quality; boosted self-confidence.

Symptom	Improvement
Severe difficulty; tongue atrophy; ventilator-dependent.	Voluntarily discontinued ventilator; independent breathing 1.25 hours; reduced lung inflammation.
Liquid via PEG tube; 30-min meals; choking risk.	Enhanced lip closure/chewing; reduced choking; upbeat mood & appetite.
Arms: Unable to lift/hold. - Legs: Tip-toed; no movement.	Restored foot reflex; reduced muscle tone; feet flat for balance; improved mobility.
Severe atrophy (limbs, hands); cold extremities.	Warmer limbs via acupoint therapy; improved circulation for tissue repair.
Stiffness, fatigue, poor sleep, low mental state.	Body relaxation; excellent mental state; boosted confidence.

Progress Summary & Future Outlook

Looking ahead, the patient's current positive progress holds great promise. In the coming weeks, with continuous rehabilitation training, the respiratory function is likely to improve further, enabling even longer periods of independent breathing. The swallowing function may fully recover, allowing a more diverse diet. The limb strength will probably continue to strengthen, facilitating normal daily activities. With the enhanced self-confidence, the patient will be more motivated to embrace the recovery journey.