Age：6 Years old

Nationality：China

Diagnosis：Autism

Admission Date：July 2010

Patient was born in full-term caesarean section, no asphyxia after birth, good general condition. Facial skin stained yellow occurred in the second day of birth and lasted 45 days until it got better without any specific treatment. Since then the parents found out that the patient’s growth is slower than her peers, she could not sit independently until 7 months, could not climb until 9 months, could not stand independently when turned 1 year old, so she went to the PLA General Hospital and was diagnosed as “growth retardation”, was given gangliosides treatment (the specific medicine and dosage are unknown) for 10 months, patient could stand on her own then. When turned 2, patient could walk independently, but not steadily. She could not speak simple words and polyphonic words until 2 years old, but the patient could suddenly say several sentences and fully recite children’s songs after turned 2. In December, 2008, patient attended to Peking University Sixth Hospital, her autism behavior checklist got 56 points, was considered as autism and didn't receive any specific treatment. Then she attended to An'ding Hospital in April, 2009, was given risperidone treatment (unknown dosage and administration ) but did not see any improvement. Since then patient stayed home and has been treated by acupuncture and functional rehabilitation exercises, until she came to our hospital for stem cell transplantation to expect further treatment. Since the onset of disease, the patient has normal mentality，good appetite, normal stool and urine.

Patient was admitted to hospital for main complaint of “speech and mental developmental delay for more than 3 years” in July 2nd, 2010.

• Mental retardation, hyperactivity, short-tempered.
• Can speak simple words, hyperactive, do not communicate with others.
• Good memory, calculation ability, comprehension and orientation, do not cooperate the physical examination.
• Soft neck, no resistance, negative to Klinefelter's syndrome.

• One course of stem cell therapy
• Surgical method: Lumbar puncture + IV Injection
• Efficacy monitoring plan over 6 to 12 months post-treatment